Buford is a smart but sleepy bloodhound who lives deep in the murky swamp county of Fenokee. He teams up with two teenagers, Cindy Mae and her older brother Woody, and the trio solves confusing mysteries that baffle Sheriff Muletrain Pettigrew and his overeager, but dimwitted deputy Goofer McGee. Buford's abilities are expanded with ears that revolve like radar dishes, and his nose responds to clues like a geiger counter; he also howls his heart out when the moon comes out and has a running feud with a brown raccoon.